Bicotene® Natural, is a natural origin delivery system that has targeted delivery of beta-carotene, a precursor to pro-retinol, to specific skin layers. Beta-carotene on its own is not stable and degrades rapidly upon exposure to, UV radiation. The Bicosome® technology stabilizes beta-carotene as a result of the double encapsulation. It further provides 8x more effective skin penetration of beta-carotene into the epidermis compared to a liposome system. Bicotene Natural is composed of two lipid assemblies: internal smart discs that carry the active and an external lipid vesicle enclosing the discs, thereby double encapsulating the active ingredient. The vesicle delivers the smart discs to the skin, which then pass through the narrow intercellular spaces of the Stratum Corneum and reach the targeted skin layer. Smart discs are designed to reach specific skin layers where the active ingredient needs to be by tailoring the affinity of the smart discs with the environment of the target skin layers.